Endocrine Abstracts

Background: The mechanisms regulating adrenarche have not been elucidated, although evidence supports a critical role for ACTH and possibly other unidentified pituitary or adrenal contributing factors. Absent adrenarche has been described in children with a variety of sellar tumors. We describe a case series of five adults with congenital hypopituitarism and absent adrenarche.Cases: Three females and two males with “idiopathic” congenital hypop...

Objectives: GH in addition to promote linear growth during childhood influences several key metabolic processes as well. In the transition period, from late adolescence to early adulthood, GH plays an important role in skeletal mineralization and muscle mass maturation as well as in developing a favorable cardiometabolic profile. Therefore, several lines of evidence propose GH replacement to be continued if GH evaluation at the transition age fulfills established criteria. The...

Aim: Ultrasound-guided Fine Needle Aspiration Biopsy (USg-FNAB) is the most accurate modality for distinguishing malignant or possibly malignant from benign thyroid nodules. However, a certain amount of specimens turn out to be non-diagnostic or inadequate. Several factors contribute to this outcome such as the examiner’s experience, characteristics of the nodule and patient’s compliance. Understanding these factors could contribute to reduction of non-diagnostic res...

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually considered low-risk tumors with favorable prognosis. However, a small percentage behaves aggressively and controversies exist for various prognostic factors. The aim of this study was to evaluate demographic and tumor specific characteristics related to PTMC invasiveness.Patients – methods: This is a retrospective study of 510 thyroidectomized patients with PTMC who were treated in t...

Introduction: Haemophilia A and B has been associated with increased prevalence of low bone mineral density (BMD). However, no study has so far evaluated the effects of anti-osteoporotic therapy on BMD.Methods/design: The primary endpoint of this prospective study was to estimate the effect of 12-month therapy of oral ibandronate 150 mg/month on BMD in patients with haemophilia A and B. Secondary endpoint was its effect on bone turnover markers (BTM), in...

Introduction: Vitamin D concentrations during pregnancy are measured to diagnose states of insufficiency or deficiency. The aim of this study is to apply accurate assays of vitamin D forms (single hydroxylated (25(OH)D2, 25(OH)D3), double-hydroxylated (1α,25(OH)2D2, 1α,25(OH)2D3), epimers (3-epi-25(OH)D2, 3-epi-25(OH)D3)) in mothers (serum) and neonates (umbilical cord) i) to expl...

Introduction: Low levels of 25-hydroxy-vitamin D [25(OH)D] have been recognized as a new cardiovascular disease risk factor. Conflicting data exist regarding the effect of statins on 25(OH)D levels and glucose metabolism.Methods/design: This was an open-label randomized prospective comparative study evaluating the effects of atorvastatin and rosuvastatin at equivalent doses on 25(OH)D levels, glucose homeostasis and systemic inflammation in non-diabetic ...

Fine needle aspiration is used extensively in the diagnostic evaluation of thyroid nodules. However, its diagnostic efficacy may be reduced by non-diagnostic findings. The aim was to study the effect of nodule size on the diagnostic efficacy of ultrasound-guided fine needle aspiration biopsy in thyroid nodules.Ultrasound-guided fine needle aspiration biopsy was performed in 210 patients with thyroid nodules. Cytology results were compared to nodule size....

Ultrasound-guided fine needle aspiration biopsy is used extensively in the diagnostic evaluation of thyroid nodules. However, its diagnostic efficacy is hampered by the presence of non-diagnostic cytology results.The aim was to study the effect of previous thyroxine suppression therapy on the diagnostic efficacy of fine needle aspiration biopsy in thyroid nodules.Ultrasound-guided aspiration biopsy was performed in 45 patients, 31 ...

Background: While the association between cigarette smoking and type 2 diabetes is established, the impact of smoking on developing gestational diabetes mellitus (GDM) remains controversial.Aim: To investigate whether maternal cigarette smoking during pregnancy is a risk factor for developing GDM.Methods: MEDLINE, Scopus, CENTRAL and Google Scholar databases were searched from inception to December 2022 to identify eligible origina...